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Measures > Measure Information
TSH, T4, fT4 Index
General Information
Measure Name: TSH, T4, fT4 Index
Measure Type:
Construct: Biomarkers - Thyroid Hormones
Primary Content Area: Obesity
Secondary Content Area:
Brief Description: Diet-induced weight loss is accompanied by a decline in thyroid stimulating hormone (TSH), Triidothyronine (T3), and T4, similar to “sick euthyroid syndrome” (1,2), and thyroid-hormone repletion in weight-reduced individuals has recently been reported to resolve some of the peripheral adaptive responses thought to drive weight regain in a manner similar to what is seen following thyroid repletion in hypothyroid individuals (3,4). Other factors commonly measured when assessing thyroid status (T3, reverse T3) present a significant burden for researchers because of the expense of these assays and are suggested only when resources are available.

1. Rosenbaum M, Hirsch J, Murphy E, Leibel R. The effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function. Amer J Clin Nutr 2000;71:1421-1432.
2. Sumithran P, Prendergast L, Delbridge E, et al. Long-term persistance of hormonal adaptations to weight loss. N Eng J Med 2011;365:1597-604.
3. Caiozzo V, Baker M, Baldwin K. Novel transitions in MHC isoforms: separate and combined effects of thyroid hormone and mechanical unloading. J Appl Physiol 1998;85:2237-2248.
4. Canepari M, Cappelli V, Pellegrino M, Zanardi M, Reggiani C. Thyroid hormone regulation of MHC isoform composition and myofibrillar ATPase activity in rat skeletal muscles. Arch Physiol Biochem 1998;106:308-315.
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(Last Updated: 3/19/2018 11:47:20 AM by Paul MacLean)

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