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Measures > Measure Information
Metabolite Panel - Glucose, NEFA, TG
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Measure Name: Metabolite Panel - Glucose, NEFA, TG
Measure Type: Scale
Construct: Biomarkers - Nutrient Status
Primary Content Area: Nutrition
Secondary Content Area: Obesity
Brief Description: Nutrient-sensing systems in peripheral tissues and in specific regions of the hypothalamus exist that convey signals of nutrient availability for appetite regulation and, therefore, serve as indices of nutrient status. Fasting levels of glucose, nonesterified fatty acids (NEFA), and triglycerides (TG) should be measured at baseline, during weight loss, and after weight loss. Glucose, NEFA, and TGs are the primary nutrients in circulation, and all three respond to calorie-restricted weight loss (1). TGs are also thought to affect the sensitivity of the brain to peripheral hormones through their effects on blood brain barrier transport. These metabolites consistently change with diet induced weight loss in a manner that could elevate appetite (1), and the assays are relatively inexpensive and commonly used in clinical research. As with the gut peptides, the measuring postprandial responses of these molecules is not feasible in all studies. For these reasons, acquiring postprandial responses in glucose, NEFAs, and TGs is suggested only when resources are available.

1. Maclean P, Bergouignan A, Cornier M, Jackman M. Biology’s response to dieting: the impetus for weight regain. Amer J Regul Integr Comp Physiol 2011;301:R581- R600.
Keywords: fuel, nutrient sensing
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Mode of Administration: Who Administered: Researcher
How Administered: In-person
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(Last Updated: 3/19/2018 12:25:16 PM by Paul MacLean)

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