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Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures (November, 2017) (NIH)

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The Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures Project aims to advance adult obesity treatment in the face of well-documented individual variability in response to a wide range of treatment modalities (MacLean P et al, 2018).  There is a growing understanding that this variability is due to a combination of behavioral, biological, environmental, and psychosocial factors but at present we lack datasets to comprehensively identify these factors and examine how they interact to influence treatment response. This workspace contains a list of core measures to assess high priority constructs from the four ADOPT domains: behavioral, biological, environmental, and psychosocial. 

ADOPT provides a framework for how obesity researchers can generate the evidence base needed to guide the development of tailored and potentially more effective strategies for the treatment of obesity. The identification of a core set of measures to be used in a consistent manner across adult weight loss trials represents a first step in an ongoing process which will be refined and updated dynamically as the science advances. The accumulation of data on key factors across the four ADOPT domains -- behavioral, biological, environmental, and psychosocial -- should generate a more precise description of the interplay among these factors and their coordinated impact on treatment responses, which, in turn, can inform the design and delivery of effective, tailored obesity treatments.

The workspace is intended to provide the broader scientific community with supporting information about these measures and to facilitate consistency in data collection and interdisciplinary collaboration.  Within this workspace, GEM users can update or add supporting information for these constructs and measures, comment on them, and rate them. The core measures list also can be found in the document titled “ADOPT Core Measures November 2017” in the Useful Links and Documentation section below.  This initial list is comprised of the most promising constructs and measures based on the currently available evidence.

Note, that new constructs or measures cannot be added through this workspace. The Working Group recognized that there are many potentially important measures being developed and refined, as well as newer and more promising constructs that will need to be considered in future revisions of this list as the science advances. To facilitate this work, there are four ADOPT working lists in GEM in which you can enter additional constructs and measures into GEM for consideration in future revisions of ADOPT:

Useful Links & Documentation
NameDescriptionTypePosted ByDate Posted
PAR-18-105: Ancillary Studies to Identify Behavioral and/or Psychological Phenotypes Contributing to Obesity (R01 Clinical Trial Optional) The purpose of this Funding Opportunity Announcement (FOA) is to encourage grant applications to support the addition of measures of psychological and/or behavioral constructs or weight-related variables (e.g.; BMI, body composition) to existing or new research studies in humans with the goal of elucidating behavioral or psychological phenotypes that explain individual variability in weight trajectory or response to obesity prevention or treatment interventions.URLHolly Nicastro10/2/2018
MacLean et al Obesity 2018 ADOPT Core Measures overview paperapplication/pdfHolly Nicastro4/20/2018
Lytle et al 2018 Obesity Behavioral domain paperapplication/pdfHolly Nicastro4/20/2018
Rosenbaum et al 2018 Obesity Biological domain paperapplication/pdfHolly Nicastro4/20/2018
Saelens et al 2018 Obesity Environmental domain paperapplication/pdfHolly Nicastro4/20/2018
Sutin et al Obesity 2018 Psychosocial domain paperapplication/pdfHolly Nicastro4/20/2018
PAR-18-643: NHLBI Clinical Ancillary Studies This Funding Opportunity Announcement (FOA) seeks to accelerate the pace and expand the breadth of scientific research on the clinical course, prevention and treatment of diseases within NHLBI's mission by leveraging ongoing clinical research studies through ancillary studies. This FOA invites research project applications to conduct ancillary studies to clinical research studies, including clinical trials, prospective observational studies, and/or registries. Applications submitted to this FOA should propose to collect new information and/or biological samples from participants of the ongoing parent study, and should address new research questions that are beyond those specified in the approved protocol of the parent study and are within the scientific mission of the NHLBI. URLHolly Nicastro3/19/2018
GEM Tutorial  application/pdfHolly Nicastro3/16/2018
      Workspace Status: Archived (02/16/18)


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